Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
نویسنده
چکیده
The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms can lead to compounds with a strong preference for forming one type of adduct with DNA.
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ورودعنوان ژورنال:
- Metal-Based Drugs
دوره 1 شماره
صفحات -
تاریخ انتشار 1994